Parameters Group Studied

(N = 20)

Systolic Blood Pressure

(mmHg)

Serum Tumor Necrosis Factor-Alpha (TNF-α)

Concentration (ng/ml)

Myocardial Homogenate

Reduced Glutathione

(GSH)

(µmol/g Tissue)

Malondyaldehyde

(MDA)

(mol/g Tissue)

Normal control gp.

131 ± 4.5

6.12 ± 0.34

100.42 ± 3.79

4.19 ± 0.3

Hypertensive gp.

190 ± 5.9^ac

20.22 ± 0.67^ac

411.23 ± 5.21^ac

2.11 ± 0.2^ac

Sitaglipten treated gp.

170 ± 4.2^abc

15.69 ± 0.73^abc

200.05 ± 4.99^abc

3.01 ± 0.1^abc

Captopril treated gp.

155 ± 3.9^abc

14.31 ± 0.69^abc

150.39 ± 6.69^abc

3.05 ± 0.2^abc

Sitaglipten and captopril treated gp.

132 ± 3.3^b

9.84 ± 0.92^ab

121.21 ± 7.53^ab

4.08 ± 0.3^b

F (p)

323.026^* (<0.001)

610.160^* (<0.001)

4702.247^* (<0.001)

137.52^* (<0.001)